TORAYMYXIN PMX-20R Extracorporeal Hemoperfusion Cartridge for the Endotoxin Removal.
Device description TORAYMYXIN PMX-20R (PMX) is an extracorporeal hemoperfusion cartridge intended for the selective removal of endotoxin from circulating blood through direct hemoperfusion (DHP).
The PMX cartridge (cartridge) contains fibers made of polystyrenederivatives (alphachloro-aceto-amidomethylated polystyrene). Polymyxin B is immobilized on the surface of these fibers. This fixed Polymyxin B adsorbs and removes endotoxin from the patient’s circulating blood.
Polymyxin B immobilized fibres (schematic model).
Indications for use PMX is indicated for use in the treatment of patients with sepsis or septic shock caused by gram-negative bacteria, who meet the following conditions: - Endotoxemia or suspected gram-negative infection, and - Systemic Inflammatory Response Syndrome (SIRS), as defined by the presence of at least two of the following four conditions: - Fever or hypothermia (body temperature of above 38°C or below 36°C) - Tachycardia (heart rate of above 90 bpm) - Tachypnea [(respiratory rate of above 20 breaths/min, or PaCO2 below 4.3 kPa (32mmHg)] - White blood cell count of above 12,000 cells/mm3, below 4,000 cells/mm3 or above 10% immature (band) forms.
Polymyxin B immobilized fibres (schematic model).